After a particularly rough cat and mouse fight, Jerry quits! Tom is stunned as he watches his little friend storm off to his hole, pack up his belongings and leave. First, Jerry tries moving in next door but that's where Bruno lives. Jerry settles for the house on the other side of his old digs where a rather large, sedentary cat lives. At first, Jerry enjoys his unfettered access to the kitchen but it has its drawbacks: he's constantly having to expand the opening to his new hole because of his weight gain. He first looks to Spike for companionship but that doesn't end well. Then he actively seeks a new mouse-mate, but there's a lot of crazy mice out there, especially one named Mickey. Then Tom and Jerry catch a glimpse of each other through the windows of their adjacent houses. One thing leads to another and the chase that's been happening for decades, continues.